The late Italian comic book artist Andrea Pazienza made a couple of references to Frank Zappa in his artwork.
The panel on the right is taken from his famous "The Extraordinary Adventures Of Pentothal".
below panel is also taken from a Pentothal adventure. It cites Zappa's "The Torture Never Stops"
and got published aroud1977 / 1978.
-- info & scan: makxx (Massimo)